Suramin reduces the minimum alveolar concentration of sevoflurane

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Effects of Lidocaine, Dexmedetomidine or Their Combination on the Minimum Alveolar Concentration of Sevoflurane in Dogs

The aim of this study was to determine the effects of lidocaine (LIDO) and dexmedetomidine (DEX) or their combination (LIDO-DEX), administered by constant-rate infusion (CRI), on the minimum alveolar concentration (MAC) of sevoflurane in dogs. Seven healthy mongrel dogs were used with a 2-week washout interval between treatments in this study. Anesthesia was induced with propofol and maintained...

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Minimum alveolar concentration: A reconsideration

Minimum alveolar concentration (MAC), served as the vital concept for standard measure of potency for inhaled volatile anesthetic agents, has been employed in anesthetic practice for more than 50 years. A re-consideration in the connotation and influence factors on MAC is introduced in this article. MAC actually indicates “median effective dose (ED50) for immobility”, but it is at least not com...

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Influence of sepsis on sevoflurane minimum alveolar concentration in a porcine model.

Sevoflurane is widely used in anaesthetic protocols for patients undergoing surgical procedures. However, there are no reports on the influence of sepsis on minimum alveolar concentration of sevoflurane (MAC(SEV)) in animals or in humans. The aim of this study was to test the hypothesis that sepsis could alter the MAC(SEV) in a normotensive septic pig model. Twenty young, healthy pigs were used...

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Additive contribution of nitrous oxide to sevoflurane minimum alveolar concentration for tracheal intubation in children.

BACKGROUND To study the interaction between nitrous oxide and sevoflurane during trachea intubation, the authors determined the minimum alveolar concentration of sevoflurane for tracheal intubation (MAC(TI)) with and without nitrous oxide in children. METHODS Seventy-two children aged 1-7 yr were assigned randomly to receive one of three end-tidal concentrations of nitrous oxide and one of fo...

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ژورنال

عنوان ژورنال: Japanese Journal of Pharmacology

سال: 1998

ISSN: 0021-5198

DOI: 10.1016/s0021-5198(19)40729-4